This training tool is based on the Web-based module on the same topic and is the fourth of the five-part Transgender Training Curriculum for HIV Research. This training tool is available to help facilitate in-person trainings at your site or in the community and includes a PowerPoint presentation, facilitator’s guide, a list of definitions, scenarios for discussion, and a selected list of resources. The course is intended for all staff at the NIH-funded HIV/AIDS clinical trials networks and sites and other research partners and stakeholders.